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KMID : 1149120220190010009
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Journal of the Korean Society for Psoriasis
2022 Volume.19 No. 1 p.9 ~ p.13
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Dimethyl Fumarate: A literature Review on the Effectiveness and Safety of Psoriasis Treatment
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Hyeong Jin-Hyeok
Park Eun-Joo
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Abstract
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Psoriasis is a chronic inflammatory skin conditions, and numerous therapeutic options are in place. In particular, methotrexate, cyclosporine, acitretin are commonly used as systemic treatment. In European countries, fumaric acid ester (FAE) is a common option over 20 years. Recently, dimethyl fumarte (DMF), is approved by KFDA, which is a component of FAE. DMF is a drug that has immunomodulatory and anti-inflammatory effect that is proved for treatment of plaque type psoriasis. DMF is proved for its non inferior efficacy comparing FAE. There are several side effects of DMF, such as diarrhea, facial flushing, and lymphopenia but they are easily controlled by adjustment of dosage and laboratory monitoring. DMF is a relatively safe drug for patients with underlying diseases with impaired liver or kidney function, and it has relatively low drug-drug interaction. Because of these reasons, the drug has longer drug survival rate comparing other systemic treatments even if its relatively lower efficacy. In conclusion, DMF can be used in various conditions in plaque type psoriasis patients.
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KEYWORD
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Dimethyl fumarate, Drug survival rate, Fumaric acid ester, Psoriasis
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